N-((1-(2-(tert-ButylaMino)-2-oxoethyl)piperidin-4-yl)Methyl)-3-chloro-5-fluorobenzaMide
- Product Name
- N-((1-(2-(tert-ButylaMino)-2-oxoethyl)piperidin-4-yl)Methyl)-3-chloro-5-fluorobenzaMide
- CAS No.
- 1199236-64-0
- Chemical Name
- N-((1-(2-(tert-ButylaMino)-2-oxoethyl)piperidin-4-yl)Methyl)-3-chloro-5-fluorobenzaMide
- Synonyms
- Z-944;Ulixacaltamide;Ulixacaltamide (Z944);N-[[1-[2-(tert-butylamino)-2-;Ca channels,Inhibitor,Calcium Channel,Ca2+ channels,Z944,inhibit;N-((1-(2-(tert-ButylaMino)-2-oxoethyl)piperidin-4-yl)Methyl)-3-chloro-5-fluorobenzaMide;4-[[(3-Chloro-5-fluorobenzoyl)aMino]Methyl]-N-(1,1-diMethylethyl)-1-piperidineacetaMide;1-Piperidineacetamide, 4-[[(3-chloro-5-fluorobenzoyl)amino]methyl]-N-(1,1-dimethylethyl)-
- CBNumber
- CB72543885
- Molecular Formula
- C19H27ClFN3O2
- Formula Weight
- 383.89
- MOL File
- 1199236-64-0.mol
N-((1-(2-(tert-ButylaMino)-2-oxoethyl)piperidin-4-yl)Methyl)-3-chloro-5-fluorobenzaMide Property
- Melting point:
- 122-124°C
- Boiling point:
- 528.1±50.0 °C(Predicted)
- Density
- 1.166±0.06 g/cm3(Predicted)
- storage temp.
- Refrigerator
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- pka
- 13.65±0.46(Predicted)
- form
- Solid
- color
- White to Off-White
N-Bromosuccinimide Price
- Product number
- 27679
- Product name
- Z944
- Packaging
- 1mg
- Price
- $32
- Updated
- 2024/03/01
- Product number
- 27679
- Product name
- Z944
- Packaging
- 25mg
- Price
- $571
- Updated
- 2024/03/01
- Product number
- 27679
- Product name
- Z944
- Packaging
- 5mg
- Price
- $139
- Updated
- 2024/03/01
- Product number
- 27679
- Product name
- Z944
- Packaging
- 10mg
- Price
- $243
- Updated
- 2024/03/01
- Product number
- 6367
- Product name
- Z944
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $936
- Updated
- 2021/12/16
N-((1-(2-(tert-ButylaMino)-2-oxoethyl)piperidin-4-yl)Methyl)-3-chloro-5-fluorobenzaMide Chemical Properties,Usage,Production
Description
Z944 is an inhibitor of T-type calcium channels (IC50s = 0.050-0.160 μM for the human recombinant voltage-gated calcium (Cav) channels Cav3.1, Cav3.2, and Cav3.3). It is selective for T-type channels over the N-type Cav2.2 channel (IC50 = 11 μM), as well as the rat L-type Cav1.2, human-ether-a-go-go (hERG/Kv11.1) potassium, and human voltage-gated sodium (Nav) channel Nav1.5 (IC50s = 32, 7.8, and 100 μM, respectively). Z944 (30 mg/kg) reduces the seizure duration and the amount of time rats spend in seizures in a model of absence epilepsy. It delays seizure progression in amygdala-kindled rats but does not inhibit seizures in fully kindled rats.
Chemical Properties
White Solid
Uses
As N-Piperidinyl acetamide derivatives, N-((1-(2-(tert-ButylaMino)-2-oxoethyl)piperidin-4-yl)Methyl)-3-chloro-5-fluorobenzaMide can be used as calcium channel blockers and their use in the treatment of obesity.
Definition
ChEBI: Ulixacaltamide is a member of piperidines, a member of benzamides, a member of monochlorobenzenes, a member of monofluorobenzenes and a secondary carboxamide. It has a role as a T-type calcium channel blocker and a non-narcotic analgesic.
storage
Store at +4°C